Phenytoin normalizes exaggerated fear behavior in p-chlorophenylalanine (PCPA)-treated rats
نویسندگان
چکیده
منابع مشابه
Endocrinological and behavioural effects of p-chlorophenylalanine (PCPA) oral administration to broody turkey hens (Meleagris gallopavo).
Changes in plasma levels of prolactin and LH, feed intake, water consumption, behavioural pattern and ovarian activity were recorded after oral administration of PCPA to broody turkey hens. A decrease in prolactin concentration was measured, from day 3, in 3 out of the 5 birds treated with 100 mg PCPA/kg body weight (BW) for 3 consecutive days. In these hens, broodiness was disrupted on day 6 a...
متن کاملSimulation of Phenylketonuria in Rats by Extended p-Chlorophenylalanine Treatment
The brain damage which occurs in untreated phenylketonuria probably results from the high plasma phenylalanine concentration prevailing in this condition, as treatment with a low-phenylalanine diet mitigates the situation. The actual cause of the brain damage is not known, but investigations have been carried out with high phenylalanine loads to simulate phenylketonuria and so elucidate the nat...
متن کاملFear and anxiety behavior in rats
Fear can be considered as a functional defense behavior to protect living beings against dangerous situation. In our studies we have investigated the fear behavior in rats in elevated plus maze .The increase in two parameters percent of open arm entries (%OAE) and percent of time spent in the open arms (% OAT) and decrease in the percent of time spent in closed arm (%CAT) was considered as fear...
متن کاملFear and anxiety behavior in rats
Fear can be considered as a functional defense behavior to protect living beings against dangerous situation. In our studies we have investigated the fear behavior in rats in elevated plus maze .The increase in two parameters percent of open arm entries (%OAE) and percent of time spent in the open arms (% OAT) and decrease in the percent of time spent in closed arm (%CAT) was considered as fear...
متن کاملPersistently exaggerated startle responses in rats treated with pyridostigmine bromide.
Troops in the Persian Gulf War have registered complaints consistent with CNS dysfunction that emerged after returning from the Gulf. A common experience among Persian Gulf War veterans was exposure to pyridostigmine bromide (PB) for prophylaxis against nerve gas exposure. To determine whether PB causes emergent CNS dysfunction, Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats were given PB for ...
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ژورنال
عنوان ژورنال: Epilepsy & Behavior
سال: 2006
ISSN: 1525-5050
DOI: 10.1016/j.yebeh.2006.09.002